P6279The mediating role of Mediterranean diet on the association between cardiovascular disease risk and Lp(a) levels (2024)

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A Foscolou, L Rallidis, A L Matalas, D B Panagiotakos, P6279
The mediating role of Mediterranean diet on the association between cardiovascular disease risk and Lp(a) levels, European Heart Journal, Volume 39, Issue suppl_1, August 2018, ehy566.P6279, https://doi.org/10.1093/eurheartj/ehy566.P6279

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Background/Introduction: Lipoprotein-alpha (Lp(a)) levels have been identified as a risk factor for atherosclerotic diseases such as coronary heart disease and stroke. Diet and healthy lifestyle have long been associated with both cardiovascular disease (CVD) risk.

Purpose: The aim of the present work was to evaluate a combined hypothesis regarding the modified effect of dietary habits on the association between Lp(a) and cardiovascular disease risk.

Methods: Information from a sample of n=3042 men and women were used. Participants were divided into three age categories: <45 years, 45–60 years and >60 years. Dietary habits were assessed through MedDietScore -an index assessing adherence to the Mediterranean diet with theoretical range 0–55.

Results: After adjusting for age, sex, BMI, physical activity and smoking habits, MedDietScore was inversely associated with Lp(a) levels. For individuals up to 45 years old, there was an inverse relationship between MedDietScore and Lp(a) levels (b±SE: -0.20±0.10, p=0.04); while, no significant association was observed for individuals of 45–60 years of age (p=0.88) and over 60 years old (p=0.22). When MedDietScore was included in the multi-adjusted model that evaluated Lp(a) levels and 10-year CVD incidence of the participants, the previously observed positive association between Lp(a) levels and CVD risk (p=0.04) was disappeared (p=0.15), in the overall sample, as well as in all age groups.

Conclusions: Adherence to a healthy dietary pattern, like the Mediterranean diet seems to mediates the strong association between high Lp(a) levels with CVD risk, independent of age.

Acknowledgement/Funding: Hellenic Cardiology Society (HCS2002) and the Hellenic Atherosclerosis Society (HAS2003)

This article is published and distributed under the terms of the Oxford University Press, Standard Journals Publication Model (https://academic.oup.com/journals/pages/about_us/legal/notices)

Topic:

mediterranean diet
heart disease risk factors

Issue Section:

Tuesday 28 August 2018

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